![]() ![]() ![]() Muller had an immediate impact on the development of some of the original GEMMs of mammary carcinogenesis. With his remarkable aptitude for molecular biology and genetics, Prof. By allowing the transformation of genetically normal cells to be studied in an intact tissue environment, as opposed to the prevailing models of the time that used immortalized cell lines grown under artificial culture conditions, these early GEMMs were a true test of the transforming nature of putative oncogenes. These efforts led to the development of the first GEMM of breast cancer (the MMTV-H-Ras model) in the Leder group. Philip Leder at Harvard, one of the epicentres of this rapidly emerging research area, with a major focus on adapting a genetic element known as the mouse mammary tumor virus long terminal repeat (MMTV-LTR) to drive transgene expression in the mouse mammary epithelium. He had the foresight to join the group of Prof. Muller developed a strong interest in developing transgenic mice as models of cancer, a field which at that time was at its very beginning. His original research focus was on tumor virology, where he made important contributions to our understanding of the genetic elements and mechanisms regulating DNA replication and gene expression in polyomaviruses.įollowing his graduation, Prof. Muller completed his Ph.D in 1986 at McMaster University, in the group of Prof. They have been a major factor in the development of breast cancer therapies, from targeted therapies against driving oncogenes to the latest immunotherapies, and continue to be relied on for cutting-edge translational studies by Prof. Muller with colleagues around the world, have proven to be indispensable for understanding breast cancer at the molecular, cellular and organismal levels. These vital tools, shared widely by Prof. Muller is a trailblazer who was instrumental in establishing the field of genetically engineered mouse models (GEMMs) of breast cancer. This legacy continues to have a major impact on breast cancer research and care.Ībove all, however, Prof. He is an established leader of the international breast cancer research community and a cornerstone of McGill’s cancer research and training programs who has helped to launch and support the careers of many scientists and clinicians. ![]() Muller’s independent career of over 30 years has been distinguished by many outstanding scientific discoveries and contributions. ![]()
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